Funding opportunities
Open and upcoming programs from Canadian funders and US federal grants (Grants.gov). Deadlines first, then rolling intakes.
Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)
National Institutes of Health · Deadline 2026-11-19
The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications that bundle independent protocols for phase 1 clinical trials with phase 1b/phase 2a clinical trials to streamline the early-stage evaluation of promising pharmacological interventions for Alzheimer's disease (AD) and Alzheimer's disease-related Dementias (ADRD). Candidate interventions evaluated through this program, which can include small molecules or biologics for example, must engage non-amyloid/non-tau mechanisms and aim to address cognitive and/or neuropsychiatric symptoms in individuals across the spectrum from pre-symptomatic to more severe stages of disease. This NOFO uses the UG3/UH3 phased award mechanism and proposals must include prespecified, go/no-go safety and tolerability milestones that gate the advance from phase 1 to latter stages of clinical development.
DoW Toxic Exposures Clinical Trial Award
Defense Health Agency Contracting Activity - DHACA · Deadline 2026-11-19
Summary: The fiscal year 2026 (FY26) Toxic Exposures Research Program (TERP) Clinical Trial Award (CTA) mechanism supports the advancement, execution, and analysis of clinical trials with the potential to have a significant impact on the prevention, treatment, or management of symptoms, diseases or conditions associated with or resulting from military-related toxic exposures. Proposed projects may range from small proof-of-concept clinical trials (e.g., pilot, first-in-human, phase 0) designed to demonstrate the feasibility or inform the design of more advanced trials, through large-scale trials (including pragmatic clinical trials) to determine efficacy in relevant patient populations. Distinctive Features: To encourage applications that include meaningful and productive collaborations, the FY26 TERP CTA includes a Partnering Principal Investigator Option (PPIO) . One Principal Investigator (PI) is identified as the initiating PI, and an additional PI may be identified as a Partnering PI. If recommended for funding, each PI will be named on separate awards. The intent is to support interdisciplinary partnerships, such as those between clinicians and research scientists, that will
DoW Toxic Exposures Investigator Initiated Research Award
Defense Health Agency Contracting Activity - DHACA · Deadline 2026-11-19
Summary: The fiscal year 2026 Toxic Exposures Research Program (TERP) Investigator-Initiated Research Award (IIRA) is intended to support studies that will make an important contribution toward research and/or patient care for diseases or conditions associated with military-related toxic exposures. Research projects may focus on any phase of research from basic laboratory research through translational research, including preclinical studies in animal models and human subjects, as well as correlative studies associated with an existing clinical trial. New Approach Methodologies may also be used. https://cdmrp.health.mil/pubs/press/2026/terppreann
DoW Toxic Exposures Translational Research Award
Defense Health Agency Contracting Activity - DHACA · Deadline 2026-11-19
Summary: The intent of the fiscal year 2026 (FY26) Toxic Exposures Research Program (TERP) Translational Research Award (TRA) is to support translational research that will accelerate the movement of promising ideas in military-related toxic exposure research into clinical applications, including health care products, interventions, technologies and/or clinical practice guidelines. Translational research may be defined as an integration of basic science and clinical observations. New Approach Methodologies may also be used. Applications should provide evidence for the reciprocal transfer of information between basic and clinical science, or vice versa, in developing and implementing the research plan. Distinctive Features: To encourage applications that include meaningful and productive collaborations, the FY26 TERP TRA includes a Partnering Principal Investigator Option (PPIO). One Principal Investigator (PI) is identified as the initiating PI, and an additional PI may be identified as a Partnering PI. If recommended for funding, each PI will be named on separate awards. The intent is to support interdisciplinary partnerships, such as those between clinicians and research scientis
Easement Restoration and Stewardship
Natural Resources Conservation Service · Deadline 2026-11-19
The opportunities associated with this NOFO are for lands protected through the Wetland Reserve Easements (WRE) component of the Agricultural Conservation Easement Program (ACEP) and the Floodplain Easement (FPE) component of the Emergency Watershed Protection Program (EWPP). The types of work available through this opportunity fall into three primary categories: 1) restoration of wetland and floodplain easements; 2) stewardship of wetland and floodplain easements, and 3) onsite and offsite assessment of easement conditions. Component 1) Wetland and Floodplain Easement Restoration. Awardees will work with NRCS personnel, partners and landowners to develop and implement sound easement restoration plans. These plans may include structural practices, such as levees and water control structures, and/or vegetative establishment practices, such as tree planting. Awardees are expected to complete the following easement restoration activities: (A) Coordination- Accept input on restoration planning from NRCS employees, NRCS partners and easement owners. (B) Investigation- Completion of technical surveys such as topographic, hydrological or habitat inventories. (C) Restoration Design- Combin Awards range from $250,000 to $5,000,000.
Improved quality of life of persons with disabilities in provinces heavily sprayed with agent orange in Ca Mau and Quang Ngai
U.S. Mission to Vietnam · Deadline 2026-11-19
Improve quality of life of persons with disabilities in provinces heavily sprayed with agent orange in Ca Mau and Quang Ngai Awards up to $28,500,000.
FY27 Small Business Development Center State of Kansas Network Rebid
Small Business Administration · Deadline 2026-11-19
Eligible organizations, as defined in Section 3.2, may apply to SBA for an award of financial assistance under this Funding Opportunity to fund an SBDC Program. SBDC Programs deliver professional, high quality, individualized business advising and technical assistance to existing small businesses and pre- venture entrepreneurs. SBDCs shall provide problem solving assistance to help small businesses access capital, develop and exchange new technologies, and improve business planning, strategy, operations, financial management, personnel administration, marketing, export assistance, sales and other areas required for small business growth and expansion, management improvement, increased productivity, and innovation. Awards range from $777,777 to $1,144,946.
NCI Research Specialist Award for Core and Laboratory-based Scientists (R50 Clinical Trial Not Allowed)
National Institutes of Health · Deadline not published
This notice of funding opportunity (NOFO) will invite applications for the Research Specialist Award (R50), which provides salary support for exceptional, non-tenure track scientists working in research laboratories and core facilities who make essential contributions to cancer research. The R50 is intended to support stable, long-term research careers for highly skilled scientists who contribute to NCI-funded research programs but do not serve as independent investigators. Research specialists are highly trained, highly productive scientists who are committed to a research career at the bench or dry lab. Working within laboratories, core facilities, and shared resources, they provide critical expertise, technical leadership, and continuity that strengthen the research infrastructure and enhance the productivity of cancer research across basic, translational, clinical, and population sciences. Eligible applicants must have an advanced degree, have contributed to their cancer research program for at least two years, and devote at least half their time to NCI-funded research. Applicants must not have sought independent investigator funding in the last five years. The R50 offers salar
Native American Affairs: Fiscal Year 2025 Colorado River Basin Tribal Drought Resiliency Program
Bureau of Reclamation · Deadline 2026-11-20
The objectives of this NAA/TAP funding opportunity are to provide funding for drought relief actions/projects that mitigate drought impacts for designated federally recognized tribes within the Colorado River Basin (see Eligibility section for list of tribes), and which advance Presidential and Department of the Interior Priorities within the Basin.Proposals should meet one or more of the following objectives:Mitigate drought impacts,Increase drought resiliency,Reduce reliance on declining water sources,Increase the efficiency of water deliveries,Mitigate the loss of tribal water or water related resources,Address drinking water shortages or,Advance Presidential or Department of the Interior Priorities in these areasReclamation Plans to make Fiscal Year 2025 funds available for proposals selected for this NOFO:Maximum award per tribe: $1,000,000No cost share is statutorily required; however, partnering and collaboration, including through cost sharing, is encouraged.The NAA/TAP demonstrably advances Trump administration priorities, such as those identified in Presidential Executive Order 14154 (January 20, 2025): Unleashing American Energy (E.O. 14154) and Secretarial Order 3418, a Awards range from $50,000 to $1,000,000.
Preschool Development Grant Birth Through Five (PDG B-5) SMART Grant
Administration for Children and Families · Deadline 2026-11-20
This NOFO is modified. The webinar link was changed and the ECD website address changed. The U.S. Department of Health and Human Services (HHS), Administration for Children and Families (ACF), seeks applications for the Preschool Development Grant Birth through Five (PDG B-5) SMART Grant: Strategic Measurement, Analytics, and Results using Technology. This funding opportunity will support states and territories to make targeted, one-year investments in statewide early care and education (ECE) technology and analytic data infrastructure that advance PDG B-5 purposes, including strengthening coordination across the mixed-delivery system, improving program quality and access, supporting informed family choice, and using data to better understand and address the needs of children from birth through age five. Applicants will propose a focused, feasible investment that strengthens the state's ability to generate actionable information for decision-making and produces a measurable result by the end of the project period. Awards range from $500,000 to $15,000,000.
Affordable Rural Cooperative (ARC) Energy Program
Rural Utilities Service · Deadline 2026-11-20
The Rural Utilities Service (RUS or the Agency), a Rural Development (RD) agency of the United States Department of Agriculture (USDA), is soliciting Letters of Interest (LOI) for applications under the Affordable Rural Cooperative (ARC) Program. In addition, the Agency is announcing the eligibility requirements, application process and deadlines, and the criteria that will be used by RUS to assess ARC Applications. The ARC Program is making approximately $175 million in appropriated budget authority for the cost of loan and grant funds available under the Inflation Reduction Act (IRA) of 2022. In keeping with the statutory authority for the program, RUS will utilize the ARC funds to assist Eligible Entities to achieve future net reductions consistent with Section 22004 of the IRA through the deployment of advanced, efficient transmission infrastructure and nuclear power supply. Available funds will be allocated for each purpose while advancing the long-term resiliency, reliability, and affordability of rural electric systems. All Eligible Entities are responsible for any expenses incurred in developing their LOIs and ARC Applications. This funding notice advances the statutory pur Awards range from $100,000 to $20,000,000.
F26AS00030 Cooperative Endangered Species Conservation Fund: Recovery Land Acquisition Grant Program
Fish and Wildlife Service · Deadline 2026-11-20
First awarded in fiscal year (FY) 2001, Recovery Land Acquisition grants promote State and Federal cooperation in listed species conservation by leveraging funds to acquire specific parcels of land, through fee simple or conservation easement, in support of U.S. Fish and Wildlife Service (FWS)-approved recovery plans and outlines. The Endangered Species Act (ESA) conveys the importance of recovery plans as a central organizing tool for guiding the recovery process by requiring their development for every listed species. Awards range from $10,000 to $14,162,000.
BJA FY 2026 Justice Reinvestment Initiative: Strengthening State and Local Operations to Reduce Crime and Recidivism
Bureau of Justice Assistance · Deadline 2026-11-20
This is a notice of funding opportunity (NOFO) for the BJA FY 2026 Justice Reinvestment Initiative: Strengthening State and Local Operations to Reduce Crime and Recidivism. This opportunity will support state, local, and tribal government efforts to reduce wasteful spending and inefficient uses of funds across justice system operations and redirect that funding to target crime and other public safety and/or justice system challenges. Applicants should propose projects that address one or more urgent local justice system challenge. Applicants should use existing data and information to identify the specific challenges they will focus on and how they will refocus resources on the strategies and populations most likely to reduce crime. Jurisdictions may consider addressing challenges across the judicial system, including those related to law enforcement, prosecution, sentencing, jails and prisons, probation, and parole. Awards up to $4,000,000.
BJA FY 2026 Residential Substance Abuse Treatment for State Prisoners – Formula Grants Program
Bureau of Justice Assistance · Deadline 2026-11-20
This is a notice of funding opportunity (NOFO) for the BJA FY2026 Residential Substance Abuse Treatment (RSAT) for State Prisoners Formula Grants Program. This opportunity provides formula grant funding to enhance the capabilities of state, local, and tribal governments to support residential substance use disorder (SUD) treatment to adult and juvenile populations in detention or incarceration, initiate or continue evidence-based SUD treatment in jails, prepare individuals for reintegration into the community, and assist them and their communities throughout the reentry process by delivering community-based treatment and other recovery aftercare services. This NOFO will increase access to treatment for individuals with substance use or co-occurring substance use and mental health disorders in detention or incarceration and improve continuity of care during and after reentry by delivering community-based treatment and other broad-based aftercare services. Awards up to $2,200,000.
Unlocking New Levels of Output and Capacity for Key Subsurface Resources SBIR/STTR (UNLOCK SBIR/STTR)
Advanced Research Projects Agency Energy · Deadline 2026-11-20
NOFO Number: DE-FOA-0003631 - Unlocking New Levels of Output and Capacity for Key Subsurface Resources SBIR/STTR (UNLOCK SBIR/STTR) To obtain a copy of the Notice of Funding Opportunity (NOFO) please go to DOE eXCHANGE at https://exchange.energy.gov/. To apply to this NOFO, Applicants must register with and submit application materials through DOE eXCHANGE (https://exchange.energy.gov/Registration.aspx). For detailed guidance on using DOE eXCHANGE, please refer to the DOE eXCHANGE User Guide (https://exchange.energy.gov/Manuals.aspx). ARPA-E will not review or consider application materials submitted through other means. For problems with DOE eXCHANGE, email ExchangeHelp@hq.doe.gov (with NOFO name and number in the subject line). Questions about this NOFO? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email ARPA-E-CO@hq.doe.gov. Agency Overview: The Advanced Research Projects Agency – Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. Awards range from $323,090 to $4,630,944.
Unlocking New Levels of Output and Capacity for Key Subsurface Resources (UNLOCK)
Advanced Research Projects Agency Energy · Deadline 2026-11-20
NOFO Number: DE-FOA-0003630 - Unlocking New Levels of Output and Capacity for Key Subsurface Resources (UNLOCK) To obtain a copy of the Notice of Funding Opportunity (NOFO) please go to DOE eXCHANGE at https://exchange.energy.gov/. To apply to this NOFO, Applicants must register with and submit application materials through DOE eXCHANGE (https://exchange.energy.gov/Registration.aspx). For detailed guidance on using DOE eXCHANGE, please refer to the DOE eXCHANGE User Guide (https://exchange.energy.gov/Manuals.aspx). ARPA-E will not review or consider application materials submitted through other means. For problems with DOE eXCHANGE, email ExchangeHelp@hq.doe.gov (with NOFO name and number in the subject line). Questions about this NOFO? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email ARPA-E-CO@hq.doe.gov. Agency Overview: The Advanced Research Projects Agency – Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. 111-358), as further Awards range from $3,000,000 to $5,000,000.
HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)
National Institutes of Health · Deadline 2026-11-23
The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects. Awards up to $375,000.
Cellular Senescence Network (SenNet): SenNet Technology Projects (SenTecs) (UG3/UH3 Clinical Trial Not Allowed)
National Institutes of Health · Deadline 2026-11-23
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit the development of innovative senescence technologies (SenTecs), or the adaptation of existing technologies focused on identification, characterization and understanding the biological consequences of senescent cell (SnC) heterogeneity in the context of the tissue environments and secretomes to facilitate novel strategies for modulating SnCs in vivo and for predicting the outcomes of targeting SnCs in human aging and in disease conditions. These are five-year, milestone-driven awards consisting of two phases. The first two years constitute the UG3 phase and are focused on SenTec development and demonstration of technology feasibility. The following 3-years is the SenTec application UH3 phase where SenTecs continue to be optimized, refined and validated. In the final year of the UH3 award, SenTecs will undertake a demonstration project conducted in a collaborative effort within SenNet to provide further validation of the proposed SenTec. Applicants are required to submit both UG3 and UH3 projects together when responding to this NOFO. Transition from the UG3 to UH3 phases is not automatic and will occur only afte
Cellular Senescence Network (SenNet): Discovery, Validation Centers (UM1 Clinical Trials Not Allowed)
National Institutes of Health · Deadline 2026-11-23
The purpose of this Notice of Funding Opportunity (NOFO) is to support SenNet Discovery and Validation Centers (SenNet DVCs) as a core component of Stage 2 of the NIH Common Fund Cellular Senescence Network (SenNet). Building on Stage 1 resources, DVCs will define, refine, and validate tissue- and disease-relevant cellular senescence signatures (“senotypes”) and associated biomarkers, and will investigate their functional consequences in human health and disease. DVCs are expected to generate and contribute high-quality molecular, cellular, and spatial datasets (including relevant metadata and documentation) and to use complementary experimental systems, as appropriate, to validate senotypes/biomarkers and characterize responses to senescence-associated perturbations or senotherapeutic approaches. DVC applications should also propose goals and aims for SenNet consortium-wide organizational and outreach activities (SenNet OOC functions).
Cellular Senescence Network (SenNet): SenNet Data Coordination and Integration Center (SenNet DCIC) (UM1 Clinical Trials Not Allowed)
National Institutes of Health · Deadline 2026-11-23
The purpose of this Notice of Funding Opportunity (NOFO) is to support the SenNet Data Coordination and Integration Center (SenNet DCIC) as a core component of Stage 2 of the NIH Common Fund Cellular Senescence Network (SenNet). The DCIC will enable timely, high-quality submission, harmonization, integration, and broad dissemination of SenNet-generated data and associated resources by developing and implementing consortium-wide policies, standards, and workflows for data formats, metadata, quality control, and release. The DCIC will maintain and enhance SenNet’s data infrastructure (e.g., portal and associated tools) to support data discovery, access, analysis, visualization, and reuse, and will integrate Stage 1 and Stage 2 outputs to support atlasing and cross-study comparability. DCIC applications should also propose goals and aims for SenNet consortium-wide organizational and outreach activities (SenNet OOC functions).